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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Digitoxin | |
| Synonyms |
|
|
| Definitions |
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2634 |
|
| Accepted_Therapeutic_Use_For |
Atrial Fibrillation; Atrial Flutter; Congestive Heart Failure; Supraventricular Tachyarrhythmias.
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| ALT_DEFINITION |
A substance that is being studied as a treatment for cancer.
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| CAS_Registry |
71-63-6
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| CHEBI_ID |
CHEBI:28544
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|
| Chemical_Formula |
C41H64O13
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|
| code |
C2634
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|
| Contributing_Source |
FDA
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|
| definition |
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
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|
| FDA_UNII_Code |
E90NZP2L9U
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Digitoxin
|
|
| Legacy Concept Name |
Digitoxin
|
|
| Maps_To |
Digitoxin
|
|
| NCI_Drug_Dictionary_ID |
38332
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|
| NSC Number |
7529
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|
| PDQ_Closed_Trial_Search_ID |
38332
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|
| PDQ_Open_Trial_Search_ID |
38332
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|
| Preferred_Name |
Digitoxin
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|
| prefixIRI |
NCIT:C2634
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|
| prefLabel |
Digitoxin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0012258
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|
| subClassOf |
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