loading...| Preferred Name |
Rosiglitazone Maleate |
|
| Synonyms |
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|
| Definitions |
The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2583 |
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| Accepted_Therapeutic_Use_For |
Type 2 diabetes Non-Insulin-Dependent Diabetes Mellitus and Type II Diabetes Mellitus |
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| ALT_DEFINITION |
A drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Avandia stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent. |
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| CAS_Registry |
155141-29-0 |
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| CHEBI_ID |
CHEBI:8892 |
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| Chemical_Formula |
C18H19N3O3S.C4H4O4 |
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| code |
C2583 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
| Display_Name |
Rosiglitazone Maleate |
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| FDA_UNII_Code |
KX2339DP44 |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Rosiglitazone Maleate |
|
| Legacy Concept Name |
Rosiglitazone |
|
| Maps_To |
Rosiglitazone Maleate |
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| NCI_Drug_Dictionary_ID |
37793 |
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| NSC Number |
717764 |
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| PDQ_Closed_Trial_Search_ID |
37793 |
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| PDQ_Open_Trial_Search_ID |
37793 |
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| Preferred_Name |
Rosiglitazone Maleate |
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| prefixIRI |
NCIT:C2583 |
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| prefLabel |
Rosiglitazone Maleate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0795660 |
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| subClassOf |