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Biological and Environmental Research Ontology
| Preferred Name | Pegylated Interferon Alfa | |
| Synonyms |
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| Definitions |
A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2491 |
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| Accepted_Therapeutic_Use_For |
Hepatitis C.
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|
| code |
C2491
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| Contributing_Source |
CTRP
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|
| definition |
A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
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| Display_Name |
Pegylated Interferon Alfa
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Pegylated Interferon Alfa
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|
| Legacy Concept Name |
Pegylated_Interferon_Alfa
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|
| Maps_To |
Pegylated Interferon Alfa
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| NCI_Drug_Dictionary_ID |
43151
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|
| PDQ_Closed_Trial_Search_ID |
43151
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| PDQ_Open_Trial_Search_ID |
43151
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| Preferred_Name |
Pegylated Interferon Alfa
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| prefixIRI |
NCIT:C2491
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| prefLabel |
Pegylated Interferon Alfa
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0907160
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| subClassOf |
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