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Biological and Environmental Research Ontology
| Preferred Name | Recombinant Interferon Alfa | |
| Synonyms |
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| Definitions |
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C225 |
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| Accepted_Therapeutic_Use_For |
See specific agents.
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| code |
C225
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| Contributing_Source |
CTRP
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| definition |
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
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| Display_Name |
Recombinant Interferon Alfa
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Alfa
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| Legacy Concept Name |
Therapeutic_Interferon_Alfa
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| Maps_To |
Recombinant Interferon Alfa
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| NCI_Drug_Dictionary_ID |
40467
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| PDQ_Closed_Trial_Search_ID |
40467
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| PDQ_Open_Trial_Search_ID |
40467
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| Preferred_Name |
Recombinant Interferon Alfa
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| prefixIRI |
NCIT:C225
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| prefLabel |
Recombinant Interferon Alfa
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0002199
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C225 | NCIT | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000040467 | PDQ | LOOM |