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Biological and Environmental Research Ontology
| Preferred Name | Etanercept | |
| Synonyms |
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| Definitions |
A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2381 |
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| Accepted_Therapeutic_Use_For |
juvenile arthritis; psoriatic arthritis; rheumatoid arthritis.
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| ALT_DEFINITION |
A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.
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| CAS_Registry |
185243-69-0
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| code |
C2381
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| Contributing_Source |
CTRP FDA
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| definition |
A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
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| Display_Name |
Etanercept
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| FDA_UNII_Code |
OP401G7OJC
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Etanercept
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| Legacy Concept Name |
Etanercept
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| Maps_To |
Etanercept
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| NCI_Drug_Dictionary_ID |
257809
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| PDQ_Closed_Trial_Search_ID |
257809
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| PDQ_Open_Trial_Search_ID |
257809
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| Preferred_Name |
Etanercept
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| prefixIRI |
NCIT:C2381
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| prefLabel |
Etanercept
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0717758
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| subClassOf |
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