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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Amiodarone Hydrochloride | |
| Synonyms |
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| Definitions |
The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C236 |
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| Accepted_Therapeutic_Use_For |
Ventricular Fibrillation and Ventricular Tachycardia
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| ALT_DEFINITION |
A drug used to treat certain types of abnormal heart rhythms that have not gotten better with other drugs. Amiodarone hydrochloride affects the electrical activity of the heart. It is a type of antiarrhythmic agent.
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| CAS_Registry |
19774-82-4
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| Chemical_Formula |
C25H29I2NO3.ClH
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| code |
C236
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| Contributing_Source |
FDA
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| definition |
The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.
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| FDA_UNII_Code |
976728SY6Z
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Amiodarone Hydrochloride
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| Legacy Concept Name |
Amiodarone
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| NCI_Drug_Dictionary_ID |
39410
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| NSC Number |
85442
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| PDQ_Closed_Trial_Search_ID |
39410
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| PDQ_Open_Trial_Search_ID |
39410
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| Preferred_Name |
Amiodarone Hydrochloride
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| prefixIRI |
NCIT:C236
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| prefLabel |
Amiodarone Hydrochloride
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0700442
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| subClassOf |
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