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Biological and Environmental Research Ontology
| Preferred Name | Sodium Butyrate | |
| Synonyms |
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| Definitions |
The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2337 |
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| CAS_Registry |
156-54-7
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| CHEBI_ID |
CHEBI:64103
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| Chemical_Formula |
C4H7O2.Na
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|
| code |
C2337
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| Contributing_Source |
FDA
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| definition |
The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
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| FDA_UNII_Code |
8RAS91C36W
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Sodium Butyrate
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|
| Legacy Concept Name |
Sodium_Butyrate
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|
| Maps_To |
Sodium Butyrate
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| NCI_Drug_Dictionary_ID |
39601
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| NSC Number |
174280
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| PDQ_Closed_Trial_Search_ID |
39601
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| PDQ_Open_Trial_Search_ID |
39601
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| Preferred_Name |
Sodium Butyrate
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| prefixIRI |
NCIT:C2337
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|
| prefLabel |
Sodium Butyrate
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0142812
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| subClassOf |
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