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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Aminoglutethimide | |
| Synonyms |
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| Definitions |
A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C233 |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.
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| CAS_Registry |
125-84-8
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| CHEBI_ID |
CHEBI:2654
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| Chemical_Formula |
C13H16N2O2
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| code |
C233
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| Contributing_Source |
FDA
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| definition |
A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.
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| FDA_UNII_Code |
0O54ZQ14I9
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| in_subset | ||
| label |
Aminoglutethimide
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| Legacy Concept Name |
Aminoglutethimide
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| NCI_Drug_Dictionary_ID |
39140
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| NSC Number |
330915
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| PDQ_Closed_Trial_Search_ID |
39140
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| PDQ_Open_Trial_Search_ID |
39140
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| Preferred_Name |
Aminoglutethimide
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| prefixIRI |
NCIT:C233
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| prefLabel |
Aminoglutethimide
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0002555
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| subClassOf |
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