Preferred Name |
Albuterol |
|
Synonyms |
|
|
Definitions |
A racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C215 |
|
CAS_Registry |
18559-94-9 |
|
CHEBI_ID |
CHEBI:2549 |
|
Chemical_Formula |
C13H21NO3 |
|
code |
C215 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
|
Display_Name |
Albuterol |
|
FDA_UNII_Code |
QF8SVZ843E |
|
Has_Salt_Form | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
label |
Albuterol |
|
Legacy Concept Name |
Albuterol |
|
Preferred_Name |
Albuterol |
|
prefixIRI |
NCIT:C215 |
|
prefLabel |
Albuterol |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0001927 |
|
subClassOf |