C21285

Alpha-1A adrenergic receptor (466 aa, ~51 kDa) is encoded by the human ADRA1A gene. This protein is involved in smooth muscle contraction, cell proliferation, apoptosis and signal transduction.

Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI)

Alpha-1A Adrenergic Receptor

Alpha-1A_Adrenergic_Receptor

104221

Alpha-1A Adrenergic Receptor

NCIT:C21285

Alpha-1A Adrenergic Receptor

Amino Acid, Peptide, or Protein

Receptor

P35348

C2932393