loading...| Preferred Name |
Alpha-1A Adrenergic Receptor |
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| Synonyms |
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| Definitions |
Alpha-1A adrenergic receptor (466 aa, ~51 kDa) is encoded by the human ADRA1A gene. This protein is involved in smooth muscle contraction, cell proliferation, apoptosis and signal transduction. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C21285 |
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| code |
C21285 |
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| definition |
Alpha-1A adrenergic receptor (466 aa, ~51 kDa) is encoded by the human ADRA1A gene. This protein is involved in smooth muscle contraction, cell proliferation, apoptosis and signal transduction. |
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| DesignNote |
Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI) |
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| label |
Alpha-1A Adrenergic Receptor |
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| Legacy Concept Name |
Alpha-1A_Adrenergic_Receptor |
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| OMIM_Number |
104221 |
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| Preferred_Name |
Alpha-1A Adrenergic Receptor |
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| prefixIRI |
NCIT:C21285 |
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| prefLabel |
Alpha-1A Adrenergic Receptor |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
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| Swiss_Prot |
P35348 |
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| UMLS_CUI |
C2932393 |
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| subClassOf |