loading...| Preferred Name |
Nuclear Receptor Gene |
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| Synonyms |
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| Definitions |
Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C20709 |
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| code |
C20709 |
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| definition |
Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI) |
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| Gene_Encodes_Product |
Nuclear Receptor |
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| label |
Nuclear Receptor Gene |
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| Legacy Concept Name |
Nuclear_Receptor_Gene |
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| Preferred_Name |
Nuclear Receptor Gene |
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| prefixIRI |
NCIT:C20709 |
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| prefLabel |
Nuclear Receptor Gene |
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| Semantic_Type |
Gene or Genome |
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| UMLS_CUI |
C1335077 |
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| subClassOf |