Preferred Name

Topoisomerase-II Inhibitor

Synonyms
Definitions

Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis.

ID

http://purl.obolibrary.org/obo/NCIT_C1968

CHEBI_ID

CHEBI:50750

code

C1968

definition

Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis.

label

Topoisomerase-II Inhibitor

Legacy Concept Name

Topoisomerase-II_Inhibitor

Preferred_Name

Topoisomerase-II Inhibitor

prefixIRI

NCIT:C1968

prefLabel

Topoisomerase-II Inhibitor

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C1519554

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1748

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