Preferred Name

T-Cell Differentiation in the Thymus
Synonyms
Definitions

The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.

ID

http://purl.obolibrary.org/obo/NCIT_C19317

code

C19317

definition

The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.

label

T-Cell Differentiation in the Thymus

Legacy Concept Name

Thymocyte_Development

Preferred_Name

T-Cell Differentiation in the Thymus

prefixIRI

NCIT:C19317

prefLabel

T-Cell Differentiation in the Thymus

Semantic_Type

Cell Function

UMLS_CUI

C1515432

subClassOf

http://purl.obolibrary.org/obo/NCIT_C19055

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