Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | T-Cell Differentiation | |
| Synonyms |
|
|
| Definitions |
Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C19055 |
|
| code |
C19055
|
|
| definition |
Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP)
|
|
| label |
T-Cell Differentiation
|
|
| Legacy Concept Name |
T-Cell_Development
|
|
| Preferred_Name |
T-Cell Differentiation
|
|
| prefixIRI |
NCIT:C19055
|
|
| prefLabel |
T-Cell Differentiation
|
|
| Semantic_Type |
Cell Function
|
|
| UMLS_CUI |
C1155013
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping