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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Mesna | |
| Synonyms |
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| Definitions |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C192 |
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| Accepted_Therapeutic_Use_For |
Ifosfamide-induced hemorrhagic cystitis, prophylaxis
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| ALT_DEFINITION |
A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.
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| CAS_Registry |
19767-45-4
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| Chemical_Formula |
C2H5O3S2.Na
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|
| code |
C192
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| Contributing_Source |
CTRP FDA
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|
| definition |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)
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| Display_Name |
Mesna
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| FDA_UNII_Code |
NR7O1405Q9
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
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| Is_Value_For_GDC_Property | ||
| label |
Mesna
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|
| Legacy Concept Name |
Mesna
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| Maps_To |
Mesna
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| NCI_Drug_Dictionary_ID |
39759
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| NSC Number |
113891
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| PDQ_Closed_Trial_Search_ID |
39759
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| PDQ_Open_Trial_Search_ID |
39759
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| Preferred_Name |
Mesna
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|
| prefixIRI |
NCIT:C192
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|
| prefLabel |
Mesna
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0000294
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| subClassOf |
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