loading...| Preferred Name |
Gefitinib |
|
| Synonyms |
|
|
| Definitions |
An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1855 |
|
| Accepted_Therapeutic_Use_For |
Non-Small Cell Lung Carcinoma |
|
| ALT_DEFINITION |
A drug that is used to treat certain types of non-small cell lung cancer and is being studied in the treatment of other types of cancer. It is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. |
|
| CAS_Registry |
184475-35-2 |
|
| CHEBI_ID |
CHEBI:49668 |
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| Chemical_Formula |
C22H24ClFN4O3 |
|
| code |
C1855 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04) |
|
| Display_Name |
Gefitinib |
|
| FDA_UNII_Code |
S65743JHBS |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Gefitinib |
|
| Legacy Concept Name |
Gefitinib |
|
| Maps_To |
Gefitinib |
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| NCI_Drug_Dictionary_ID |
43649 |
|
| NSC Number |
715055 |
|
| PDQ_Closed_Trial_Search_ID |
43649 |
|
| PDQ_Open_Trial_Search_ID |
43649 |
|
| Preferred_Name |
Gefitinib |
|
| prefixIRI |
NCIT:C1855 |
|
| prefLabel |
Gefitinib |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C1122962 |
|
| subClassOf |