Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

MYC Family Gene
Synonyms
Definitions

MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)
ID

http://purl.obolibrary.org/obo/NCIT_C18537
code

C18537
Contributing_Source

CTRP
definition

MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)
Display_Name

MYC Family Gene
Gene_Encodes_Product

MYC Family Protein
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C142800

http://purl.obolibrary.org/obo/NCIT_C142799
label

MYC Family Gene
Legacy Concept Name

MYC_Family_Gene
Preferred_Name

MYC Family Gene
prefixIRI

NCIT:C18537
prefLabel

MYC Family Gene
Semantic_Type

Gene or Genome
UMLS_CUI

C0026902
subClassOf

http://purl.obolibrary.org/obo/NCIT_C20420
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