loading...| Preferred Name | Suramin Sodium | |
| Synonyms |
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|
| Definitions |
A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1848 |
|
| Accepted_Therapeutic_Use_For |
African trypanosomiasis; onchocerciasis |
|
| CAS_Registry |
129-46-4 |
|
| Chemical_Formula |
C51H34N6O23S6.6Na |
|
| code |
C1848 |
|
| Contributing_Source |
FDA |
|
| definition |
A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. |
|
| FDA_UNII_Code |
89521262IH |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C41029 http://purl.obolibrary.org/obo/NCIT_C17068 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Suramin Sodium |
|
| Legacy Concept Name |
Suramin_Sodium |
|
| Maps_To |
Suramin Sodium |
|
| NCI_Drug_Dictionary_ID |
40052 |
|
| NSC Number |
34936 |
|
| PDQ_Closed_Trial_Search_ID |
40052 |
|
| PDQ_Open_Trial_Search_ID |
40052 |
|
| Preferred_Name |
Suramin Sodium |
|
| prefixIRI |
NCIT:C1848 |
|
| prefLabel |
Suramin Sodium |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0813205 |
|
| subClassOf |