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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Temsirolimus | |
| Synonyms |
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| Definitions |
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1844 |
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| Accepted_Therapeutic_Use_For |
Renal Cell Carcinoma Advanced renal cell carcinoma
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| ALT_DEFINITION |
A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor.
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| CAS_Registry |
162635-04-3
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| Chemical_Formula |
C56H87NO16
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| code |
C1844
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| Contributing_Source |
CTRP FDA
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| definition |
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.
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| Display_Name |
Temsirolimus
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| FDA_UNII_Code |
624KN6GM2T
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Temsirolimus
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| Legacy Concept Name |
CCI-779
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| Maps_To |
Temsirolimus
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| NCI_Drug_Dictionary_ID |
43369
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| NSC Number |
683864
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| PDQ_Closed_Trial_Search_ID |
43369
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| PDQ_Open_Trial_Search_ID |
43369
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| Preferred_Name |
Temsirolimus
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| prefixIRI |
NCIT:C1844
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| prefLabel |
Temsirolimus
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C1707080
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| subClassOf |
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