Preferred Name

Paroxetine Hydrochloride
Synonyms
Definitions

The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

ID

http://purl.obolibrary.org/obo/NCIT_C1837

Accepted_Therapeutic_Use_For

Depression

ALT_DEFINITION

A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).

CAS_Registry

78246-49-8

Chemical_Formula

C19H20FNO3.HCl

code

C1837

Contributing_Source

FDA

definition

The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

FDA_UNII_Code

3I3T11UD2S

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C61879

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

label

Paroxetine Hydrochloride

Legacy Concept Name

Paroxetine_Hydrochloride

NCI_Drug_Dictionary_ID

42793

PDQ_Closed_Trial_Search_ID

42793

PDQ_Open_Trial_Search_ID

42793

Preferred_Name

Paroxetine Hydrochloride

prefixIRI

NCIT:C1837

prefLabel

Paroxetine Hydrochloride

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0771019

subClassOf

http://purl.obolibrary.org/obo/NCIT_C94725

http://purl.obolibrary.org/obo/NCIT_C265

Delete Subject Author Type Created
No notes to display