loading...| Preferred Name | Paroxetine Hydrochloride | |
| Synonyms |
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| Definitions |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1837 |
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| Accepted_Therapeutic_Use_For |
Depression |
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| ALT_DEFINITION |
A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI). |
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| CAS_Registry |
78246-49-8 |
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| Chemical_Formula |
C19H20FNO3.HCl |
|
| code |
C1837 |
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| Contributing_Source |
FDA |
|
| definition |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. |
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| FDA_UNII_Code |
3I3T11UD2S |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Paroxetine Hydrochloride |
|
| Legacy Concept Name |
Paroxetine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
42793 |
|
| PDQ_Closed_Trial_Search_ID |
42793 |
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| PDQ_Open_Trial_Search_ID |
42793 |
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| Preferred_Name |
Paroxetine Hydrochloride |
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| prefixIRI |
NCIT:C1837 |
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| prefLabel |
Paroxetine Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0771019 |
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| subClassOf |