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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Plerixafor | |
| Synonyms |
|
|
| Definitions |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1777 |
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| Accepted_Therapeutic_Use_For |
Hematopoietic Stem Cell Mobilization
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| ALT_DEFINITION |
A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. Plerixafor is a type of chemokine receptor antagonist.
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| CAS_Registry |
110078-46-1
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| Chemical_Formula |
C28H54N8
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|
| code |
C1777
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| Contributing_Source |
CTRP FDA PCDC
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|
| definition |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.
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|
| Display_Name |
Plerixafor
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| FDA_UNII_Code |
S915P5499N
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Plerixafor
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|
| Legacy Concept Name |
AMD3100
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|
| NCI_Drug_Dictionary_ID |
410786
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|
| PDQ_Closed_Trial_Search_ID |
410786
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|
| PDQ_Open_Trial_Search_ID |
410786
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|
| Preferred_Name |
Plerixafor
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| prefixIRI |
NCIT:C1777
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| prefLabel |
Plerixafor
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0257001
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|
| subClassOf |
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