Preferred Name

Vincristine Sulfate

Synonyms
Definitions

The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

ID

http://purl.obolibrary.org/obo/NCIT_C1739

Accepted_Therapeutic_Use_For

Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Neuroblastoma

ALT_DEFINITION

A drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Oncovin is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.

CAS_Registry

2068-78-2

Chemical_Formula

C46H56N4O10.H2O4S

code

C1739

Contributing_Source

CTRP

FDA

definition

The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

Display_Name

Vincristine Sulfate

FDA_UNII_Code

T5IRO3534A

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C933

Has_Target

http://purl.obolibrary.org/obo/NCIT_C129655

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Vincristine Sulfate

Legacy Concept Name

Vincristine_Sulfate

Maps_To

Vincristine Sulfate

NCI_Drug_Dictionary_ID

42251

NSC Number

67574

PDQ_Closed_Trial_Search_ID

42251

PDQ_Open_Trial_Search_ID

42251

Preferred_Name

Vincristine Sulfate

prefixIRI

NCIT:C1739

prefLabel

Vincristine Sulfate

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0042680

subClassOf

http://purl.obolibrary.org/obo/NCIT_C932

http://purl.obolibrary.org/obo/NCIT_C67422

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