loading...| Preferred Name |
Vincristine Sulfate |
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| Synonyms |
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| Definitions |
The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1739 |
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| Accepted_Therapeutic_Use_For |
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Neuroblastoma |
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| ALT_DEFINITION |
A drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Oncovin is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent. |
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| CAS_Registry |
2068-78-2 |
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| Chemical_Formula |
C46H56N4O10.H2O4S |
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| code |
C1739 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
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| Display_Name |
Vincristine Sulfate |
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| FDA_UNII_Code |
T5IRO3534A |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Vincristine Sulfate |
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| Legacy Concept Name |
Vincristine_Sulfate |
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| Maps_To |
Vincristine Sulfate |
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| NCI_Drug_Dictionary_ID |
42251 |
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| NSC Number |
67574 |
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| PDQ_Closed_Trial_Search_ID |
42251 |
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| PDQ_Open_Trial_Search_ID |
42251 |
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| Preferred_Name |
Vincristine Sulfate |
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| prefixIRI |
NCIT:C1739 |
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| prefLabel |
Vincristine Sulfate |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0042680 |
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| subClassOf |