Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Heparan Sulfate Proteoglycan
Synonyms
Definitions

Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI)
ID

http://purl.obolibrary.org/obo/NCIT_C17300
CHEBI_ID

CHEBI:35721

CHEBI:24499
code

C17300
definition

Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI)
label

Heparan Sulfate Proteoglycan
Legacy Concept Name

Heparan_Sulfate_Proteoglycan
Preferred_Name

Heparan Sulfate Proteoglycan
prefixIRI

NCIT:C17300
prefLabel

Heparan Sulfate Proteoglycan
Semantic_Type

Amino Acid, Peptide, or Protein

Biologically Active Substance
UMLS_CUI

C0062503
subClassOf

http://purl.obolibrary.org/obo/NCIT_C17022
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