loading...| Preferred Name |
Calcineurin |
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| Synonyms |
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| Definitions |
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2+)-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C17275 |
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| code |
C17275 |
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| Contributing_Source |
CTRP |
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| definition |
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2+)-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI) |
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| Display_Name |
Calcineurin |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Calcineurin |
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| Legacy Concept Name |
Calcineurin |
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| Preferred_Name |
Calcineurin |
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| prefixIRI |
NCIT:C17275 |
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| prefLabel |
Calcineurin |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme |
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| UMLS_CUI |
C0054450 |
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| subClassOf |