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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Nelarabine | |
| Synonyms |
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| Definitions |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1704 |
|
| Accepted_Therapeutic_Use_For |
T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma
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| ALT_DEFINITION |
A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.
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| CAS_Registry |
121032-29-9
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| CHEBI_ID |
CHEBI:63612
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| Chemical_Formula |
C11H15N5O5
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|
| code |
C1704
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| Contributing_Source |
CTRP FDA
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|
| definition |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)
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| Display_Name |
Nelarabine
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| FDA_UNII_Code |
60158CV180
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Nelarabine
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|
| Legacy Concept Name |
Nelarabine
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|
| Maps_To |
Nelarabine
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| NCI_Drug_Dictionary_ID |
43260
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| NSC Number |
686673
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| PDQ_Closed_Trial_Search_ID |
43260
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|
| PDQ_Open_Trial_Search_ID |
43260
|
|
| Preferred_Name |
Nelarabine
|
|
| prefixIRI |
NCIT:C1704
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|
| prefLabel |
Nelarabine
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0907349
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| subClassOf |
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