loading...| Preferred Name | Rituximab | |
| Synonyms |
|
|
| Definitions |
A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1702 |
|
| Accepted_Therapeutic_Use_For |
Diffuse Large B-cell, CD20-positive, Non-Hodgkins Lymphoma (NHL) |
|
| ALT_DEFINITION |
A drug used to treat certain types of B-cell non-Hodgkin lymphoma. It is also used with other drugs to treat chronic lymphocytic leukemia and rheumatoid arthritis. It is being studied in the treatment of other types of cancer and other conditions. Rituximab binds to a protein called CD20, which is found on B-cells, and may kill cancer cells. It is a type of monoclonal antibody. |
|
| CAS_Registry |
174722-31-7 |
|
| CHEBI_ID |
CHEBI:64357 |
|
| code |
C1702 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells. (NCI04) |
|
| Display_Name |
Rituximab |
|
| FDA_UNII_Code |
4F4X42SYQ6 |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Rituximab |
|
| Legacy Concept Name |
Rituximab |
|
| Maps_To |
Rituximab |
|
| NCI_Drug_Dictionary_ID |
42613 |
|
| NSC Number |
687451 |
|
| PDQ_Closed_Trial_Search_ID |
42613 |
|
| PDQ_Open_Trial_Search_ID |
42613 |
|
| Preferred_Name |
Rituximab |
|
| prefixIRI |
NCIT:C1702 |
|
| prefLabel |
Rituximab |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
|
| UMLS_CUI |
C0393022 |
|
| subClassOf |