loading...| Preferred Name |
Histone |
|
| Synonyms |
|
|
| Definitions |
Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C16687 |
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| ALT_DEFINITION |
A type of protein found in chromosomes. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes. |
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| CHEBI_ID |
CHEBI:15358 |
|
| code |
C16687 |
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| Contributing_Source |
CTRP GDC |
|
| definition |
Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome. |
|
| Display_Name |
Histone |
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| Has_GDC_Value |
http://purl.obolibrary.org/obo/NCIT_C17460 http://purl.obolibrary.org/obo/NCIT_C16685 http://purl.obolibrary.org/obo/NCIT_C43234 http://purl.obolibrary.org/obo/NCIT_C16686 http://purl.obolibrary.org/obo/NCIT_C16683 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C177536 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C157711 |
|
| label |
Histone |
|
| Legacy Concept Name |
Histone |
|
| Preferred_Name |
Histone |
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| prefixIRI |
NCIT:C16687 |
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| prefLabel |
Histone |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| UMLS_CUI |
C0019652 |
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| subClassOf |