Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Preferred Name	Histone
Synonyms
Definitions	Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.
ID	http://purl.obolibrary.org/obo/NCIT_C16687
ALT_DEFINITION	A type of protein found in chromosomes. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes.
CHEBI_ID	CHEBI:15358
code	C16687
Contributing_Source	CTRP GDC
definition	Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.
Display_Name	Histone
Has_GDC_Value	http://purl.obolibrary.org/obo/NCIT_C17460 http://purl.obolibrary.org/obo/NCIT_C16685 http://purl.obolibrary.org/obo/NCIT_C43234 http://purl.obolibrary.org/obo/NCIT_C16686 http://purl.obolibrary.org/obo/NCIT_C16683 http://purl.obolibrary.org/obo/NCIT_C17998 http://purl.obolibrary.org/obo/NCIT_C16684
in_subset	http://purl.obolibrary.org/obo/NCIT_C177536 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C142800 http://purl.obolibrary.org/obo/NCIT_C142799
label	Histone
Legacy Concept Name	Histone
Preferred_Name	Histone
prefixIRI	NCIT:C16687
prefLabel	Histone
Semantic_Type	Amino Acid, Peptide, or Protein
UMLS_CUI	C0019652
subClassOf	http://purl.obolibrary.org/obo/NCIT_C18073

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/PR_000041244	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_15358	CHEBI	LOOM
http://purl.obolibrary.org/obo/PR_000041244	OBA	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0019652	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16687	NCIT	LOOM
http://www.projecthalo.com/aura#Histone	AURA	LOOM
http://purl.org/sig/ont/fma/fma74413	FMA	LOOM
http://purl.bioontology.org/ontology/CSP/2447-3200	CRISP	LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Histone	SEPON	LOOM
http://purl.obolibrary.org/obo/CHEBI_15358	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_15358	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_15358	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_15358	ZP	LOOM
http://purl.org/obo/owlapi/fma#FMA_74413	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/OGI.owl#Histone	OGI	LOOM
http://purl.obolibrary.org/obo/OGI.owl#Histone	OGSF	LOOM
http://www.bootstrep.eu/ontology/GRO#Histone	GRO	LOOM
http://purl.obolibrary.org/obo/BE_Histone	BE	LOOM
https://pat.nichd.nih.gov/patepigeneticentity/P00000164	EPIE	LOOM
http://purl.bioontology.org/ontology/LNC/LP16714-5	LOINC	LOOM
http://purl.obolibrary.org/obo/FPLX_Histone	FPLX	LOOM
http://purl.jp/bio/4/id/200906032407817155	IOBC	LOOM
http://purl.obolibrary.org/obo/PR_000041244	PR	LOOM