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Biological and Environmental Research Ontology
| Preferred Name | Warfarin Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1658 |
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| CAS_Registry |
129-06-6
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| CHEBI_ID |
CHEBI:10034
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| Chemical_Formula |
C19H15O4.Na
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| code |
C1658
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| Contributing_Source |
CTRP FDA
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| definition |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented.
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| Display_Name |
Warfarin Sodium
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| FDA_UNII_Code |
6153CWM0CL
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
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| Is_Value_For_GDC_Property | ||
| label |
Warfarin Sodium
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| Legacy Concept Name |
Warfarin_Sodium
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| Maps_To |
Warfarin Sodium
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| NCI_Drug_Dictionary_ID |
39740
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| PDQ_Closed_Trial_Search_ID |
39740
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| PDQ_Open_Trial_Search_ID |
39740
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| Preferred_Name |
Warfarin Sodium
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| prefixIRI |
NCIT:C1658
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| prefLabel |
Warfarin Sodium
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0376218
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| subClassOf |
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