loading...| Preferred Name |
Alpha-Fetoprotein |
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| Synonyms |
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| Definitions |
Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C16278 |
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| ALT_DEFINITION |
A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor. |
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| code |
C16278 |
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| Contributing_Source |
CTRP |
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| definition |
Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation. |
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| DesignNote |
Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink) |
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| Display_Name |
Alpha-Fetoprotein |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Alpha-Fetoprotein |
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| Legacy Concept Name |
Alpha-Fetoprotein |
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| OMIM_Number |
104150 |
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| Preferred_Name |
Alpha-Fetoprotein |
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| prefixIRI |
NCIT:C16278 |
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| prefLabel |
Alpha-Fetoprotein |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| Swiss_Prot |
P02771 |
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| UMLS_CUI |
C1307640 |
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| subClassOf |