loading...| Preferred Name | Anastrozole | |
| Synonyms |
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| Definitions |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1607 |
|
| Accepted_Therapeutic_Use_For |
Hormone Receptor-Positive Early Breast cancer |
|
| ALT_DEFINITION |
An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor. |
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| CAS_Registry |
120511-73-1 |
|
| CHEBI_ID |
CHEBI:2704 |
|
| Chemical_Formula |
C17H19N5 |
|
| code |
C1607 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04) |
|
| Display_Name |
Anastrozole |
|
| FDA_UNII_Code |
2Z07MYW1AZ |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Anastrozole |
|
| Legacy Concept Name |
Anastrozole |
|
| Maps_To |
Anastrozole |
|
| NCI_Drug_Dictionary_ID |
42540 |
|
| NSC Number |
719344 |
|
| PDQ_Closed_Trial_Search_ID |
42540 |
|
| PDQ_Open_Trial_Search_ID |
42540 |
|
| Preferred_Name |
Anastrozole |
|
| prefixIRI |
NCIT:C1607 |
|
| prefLabel |
Anastrozole |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0290883 |
|
| subClassOf |