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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Levofloxacin | |
| Synonyms |
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|
| Definitions |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1586 |
|
| ALT_DEFINITION |
A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics.
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|
| CAS_Registry |
138199-71-0
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|
| Chemical_Formula |
2C18H20FN3O4.H2O
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|
| code |
C1586
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
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| Display_Name |
Levofloxacin
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|
| FDA_UNII_Code |
6GNT3Y5LMF
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Levofloxacin
|
|
| Legacy Concept Name |
Levofloxacin
|
|
| NCI_Drug_Dictionary_ID |
37941
|
|
| PDQ_Closed_Trial_Search_ID |
37941
|
|
| PDQ_Open_Trial_Search_ID |
37941
|
|
| Preferred_Name |
Levofloxacin
|
|
| prefixIRI |
NCIT:C1586
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|
| prefLabel |
Levofloxacin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0282386
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|
| subClassOf |
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