Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

C-myb Antisense Oligonucleotide G4460
Synonyms
Definitions

A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis.
ID

http://purl.obolibrary.org/obo/NCIT_C1541
code

C1541
definition

A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis.
in_subset

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

C-myb Antisense Oligonucleotide G4460
Legacy Concept Name

LR-3001
Maps_To

C-myb Antisense Oligonucleotide G4460
NCI_Drug_Dictionary_ID

43388
NSC Number

710296
PDQ_Closed_Trial_Search_ID

43388
PDQ_Open_Trial_Search_ID

43388
Preferred_Name

C-myb Antisense Oligonucleotide G4460
prefixIRI

NCIT:C1541
prefLabel

C-myb Antisense Oligonucleotide G4460
Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI

C0253788
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1291
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