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Biological and Environmental Research Ontology
| Preferred Name | Letrozole | |
| Synonyms |
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| Definitions |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1527 |
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| Accepted_Therapeutic_Use_For |
Hormone receptor-positive early breast cancer; Delayed puberty; Endometrial cancer; Ovulatory induction
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| ALT_DEFINITION |
A drug used to treat advanced breast cancer in postmenopausal women. Letrozole causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.
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| CAS_Registry |
112809-51-5
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| CHEBI_ID |
CHEBI:6413
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| Chemical_Formula |
C17H11N5
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| code |
C1527
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| Contributing_Source |
CTRP FDA
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|
| definition |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.
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| Display_Name |
Letrozole
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| FDA_UNII_Code |
7LKK855W8I
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Letrozole
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|
| Legacy Concept Name |
Letrozole
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|
| Maps_To |
Letrozole
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| NCI_Drug_Dictionary_ID |
42086
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| NSC Number |
719345
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| PDQ_Closed_Trial_Search_ID |
42086
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| PDQ_Open_Trial_Search_ID |
42086
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|
| Preferred_Name |
Letrozole
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|
| prefixIRI |
NCIT:C1527
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| prefLabel |
Letrozole
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0246421
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| subClassOf |
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