loading...| Preferred Name |
Phenyl Acetate |
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| Synonyms |
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| Definitions |
An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1501 |
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| Accepted_Therapeutic_Use_For |
Adjunctive therapy for the prevention and treatment of hyperammonemia in the chronic management of patients with urea cycle enzymopathy |
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| ALT_DEFINITION |
A drug being studied in the treatment of cancer. |
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| CAS_Registry |
122-79-2 |
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| CHEBI_ID |
CHEBI:8082 |
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| Chemical_Formula |
C8H8O2 |
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| code |
C1501 |
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| Contributing_Source |
FDA |
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| definition |
An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04) |
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| FDA_UNII_Code |
355G9R500Y |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Phenyl Acetate |
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| Legacy Concept Name |
Phenyl_Acetate |
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| Maps_To |
Phenyl Acetate |
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| NCI_Drug_Dictionary_ID |
41664 |
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| NSC Number |
27795 |
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| PDQ_Closed_Trial_Search_ID |
41664 |
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| PDQ_Open_Trial_Search_ID |
41664 |
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| Preferred_Name |
Phenyl Acetate |
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| prefixIRI |
NCIT:C1501 |
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| prefLabel |
Phenyl Acetate |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0220893 |
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| subClassOf |