loading...| Preferred Name |
Filgrastim |
|
| Synonyms |
|
|
| Definitions |
A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1474 |
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| Accepted_Therapeutic_Use_For |
Aplastic neutropenia; Bone marrow transplantation; Cancer patients receiving myelosuppressive chemotherapy; Congenital neutropenia; Idiopathic or cyclic neutropenia; Peripheral blood progenitor cell mobilization |
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| ALT_DEFINITION |
A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that is a type of hematopoietic (blood-forming) agent. |
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| CAS_Registry |
121181-53-1 |
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| code |
C1474 |
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| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. |
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| Display_Name |
Filgrastim |
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| FDA_UNII_Code |
PVI5M0M1GW |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C186329 |
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| Is_Value_For_GDC_Property | ||
| label |
Filgrastim |
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| Legacy Concept Name |
Filgrastim |
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| Maps_To |
Filgrastim |
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| NCI_Drug_Dictionary_ID |
41057 |
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| NSC Number |
614629 |
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| PDQ_Closed_Trial_Search_ID |
41057 |
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| PDQ_Open_Trial_Search_ID |
41057 |
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| Preferred_Name |
Filgrastim |
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| prefixIRI |
NCIT:C1474 |
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| prefLabel |
Filgrastim |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0210630 |
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| subClassOf |