Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Recombinant Colony Stimulating Factor
Synonyms
Definitions

Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes that stimulate the proliferation of bone marrow cells and differentiation of stem cells into colonies of granulocytes, monocytes, or macrophages. These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways. Each appears to exert actions on several lines of progenitor cells and to influence end cell function. Treatment with colony-stimulating factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy. These factors include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF).
ID

http://purl.obolibrary.org/obo/NCIT_C387
code

C387
definition

Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes that stimulate the proliferation of bone marrow cells and differentiation of stem cells into colonies of granulocytes, monocytes, or macrophages. These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways. Each appears to exert actions on several lines of progenitor cells and to influence end cell function. Treatment with colony-stimulating factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy. These factors include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF).
label

Recombinant Colony Stimulating Factor
Legacy Concept Name

Therapeutic_Colony_Stimulating_Factor
Preferred_Name

Recombinant Colony Stimulating Factor
prefixIRI

NCIT:C387
prefLabel

Recombinant Colony Stimulating Factor
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C0376561
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1283

http://purl.obolibrary.org/obo/NCIT_C2395
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