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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Sodium Phenylbutyrate | |
| Synonyms |
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| Definitions |
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1440 |
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| Accepted_Therapeutic_Use_For |
Adjunctive therapy for urea cycle disorders involving deficiencies of carbamoylphosphate synthetase; ornithine transcarbamylase; or argininosuccinic acid synthetase; S-S and S-C sickle cell disease; S-thalassemia hemoglobinopathy
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| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called differentiating agents.
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| CAS_Registry |
1716-12-7
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| Chemical_Formula |
C10H11O2.Na
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| code |
C1440
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| Contributing_Source |
CTRP FDA
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| definition |
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
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| Display_Name |
Sodium Phenylbutyrate
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| FDA_UNII_Code |
NT6K61736T
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Sodium Phenylbutyrate
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| Legacy Concept Name |
_4-Phenylbutyrate
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| Maps_To |
Sodium Phenylbutyrate
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| NCI_Drug_Dictionary_ID |
536018
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| NSC Number |
657802
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| PDQ_Closed_Trial_Search_ID |
536018
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| PDQ_Open_Trial_Search_ID |
536018
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| Preferred_Name |
Sodium Phenylbutyrate
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| prefixIRI |
NCIT:C1440
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| prefLabel |
Sodium Phenylbutyrate
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0718066
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| subClassOf |
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