Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Tbo-filgrastim
Synonyms
Definitions

A recombinant form of the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Upon administration, tbo-filgrastim specifically binds to and activates G-CSF receptors, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. This stimulates the proliferation of neutrophils and may decrease the duration and prevent the incidence of chemotherapy-induced neutropenia (CIN). The pharmacokinetic and pharmacodynamic profile of tbo-filgrastim is bioequivalent to filgrastim.
ID

http://purl.obolibrary.org/obo/NCIT_C137803
Accepted_Therapeutic_Use_For

Cancer patients receiving myelosuppressive chemotherapy; Congenital, cyclic, idiopathic or febrile neutropenia; Peripheral blood progenitor cell mobilization
code

C137803
definition

A recombinant form of the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Upon administration, tbo-filgrastim specifically binds to and activates G-CSF receptors, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. This stimulates the proliferation of neutrophils and may decrease the duration and prevent the incidence of chemotherapy-induced neutropenia (CIN). The pharmacokinetic and pharmacodynamic profile of tbo-filgrastim is bioequivalent to filgrastim.
label

Tbo-filgrastim
NCI_META_CUI

CL524902
Preferred_Name

Tbo-filgrastim
prefixIRI

NCIT:C137803
prefLabel

Tbo-filgrastim
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
subClassOf

http://purl.obolibrary.org/obo/NCIT_C387
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