loading...| Preferred Name |
Lithium Carbonate |
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| Synonyms |
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|
| Definitions |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1318 |
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| CAS_Registry |
554-13-2 |
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| CHEBI_ID |
CHEBI:6504 |
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| Chemical_Formula |
CO3.2Li |
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| code |
C1318 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
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| Display_Name |
Lithium Carbonate |
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| FDA_UNII_Code |
2BMD2GNA4V |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Lithium Carbonate |
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| Legacy Concept Name |
Lithium_Carbonate |
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| NCI_Drug_Dictionary_ID |
39491 |
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| NSC Number |
16895 |
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| PDQ_Closed_Trial_Search_ID |
39491 |
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| PDQ_Open_Trial_Search_ID |
39491 |
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| Preferred_Name |
Lithium Carbonate |
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| prefixIRI |
NCIT:C1318 |
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| prefLabel |
Lithium Carbonate |
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| Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
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| UMLS_CUI |
C0085217 |
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| subClassOf |