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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Tacrolimus | |
| Synonyms |
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|
| Definitions |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1311 |
|
| Accepted_Therapeutic_Use_For |
Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis
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|
| ALT_DEFINITION |
A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.
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| CAS_Registry |
109581-93-3
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| CHEBI_ID |
CHEBI:61057
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|
| Chemical_Formula |
C44H69NO12.H2O
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|
| code |
C1311
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| Contributing_Source |
CTRP FDA
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|
| definition |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
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|
| Display_Name |
Tacrolimus
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|
| FDA_UNII_Code |
WM0HAQ4WNM
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Tacrolimus
|
|
| Legacy Concept Name |
Tacrolimus
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|
| NCI_Drug_Dictionary_ID |
42009
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| NSC Number |
717865
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|
| PDQ_Closed_Trial_Search_ID |
42009
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| PDQ_Open_Trial_Search_ID |
42009
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|
| Preferred_Name |
Tacrolimus
|
|
| prefixIRI |
NCIT:C1311
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|
| prefLabel |
Tacrolimus
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0085149
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| subClassOf |
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