loading...| Preferred Name | O-Chloroacetylcarbamoylfumagillol | |
| Synonyms |
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| Definitions |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1298 |
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| ALT_DEFINITION |
A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent. |
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| CAS_Registry |
129298-91-5 |
|
| code |
C1298 |
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| Contributing_Source |
FDA |
|
| definition |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04) |
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| FDA_UNII_Code |
X47GR46481 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
O-Chloroacetylcarbamoylfumagillol |
|
| Legacy Concept Name |
TNP-470 |
|
| Maps_To |
O-Chloroacetylcarbamoylfumagillol |
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| NCI_Drug_Dictionary_ID |
41725 |
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| NSC Number |
642492 |
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| PDQ_Closed_Trial_Search_ID |
41725 |
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| PDQ_Open_Trial_Search_ID |
41725 |
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| Preferred_Name |
O-Chloroacetylcarbamoylfumagillol |
|
| prefixIRI |
NCIT:C1298 |
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| prefLabel |
O-Chloroacetylcarbamoylfumagillol |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0081489 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_90748 | CHEBI | LOOM | |
| http://phenomebrowser.net/ontologies/mesh/mesh.owl#C066515 | RH-MESH | LOOM | |
| http://purl.bioontology.org/ontology/MESH/D000077609 | MESH | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1298 | NCIT | LOOM |