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Biological and Environmental Research Ontology
| Preferred Name | Vinorelbine | |
| Synonyms |
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| Definitions |
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1275 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Cervical cancer; Non-small cell lung cancer; Ovarian cancer; Prostate cancer
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
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| CAS_Registry |
71486-22-1
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| CHEBI_ID |
CHEBI:480999
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| Chemical_Formula |
C45H54N4O8
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|
| code |
C1275
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| Contributing_Source |
CTRP FDA PCDC
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| definition |
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
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| Display_Name |
Vinorelbine
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| FDA_UNII_Code |
Q6C979R91Y
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 |
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| Is_Value_For_GDC_Property | ||
| label |
Vinorelbine
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|
| Legacy Concept Name |
Vinorelbine
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|
| Maps_To |
Vinorelbine
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|
| Preferred_Name |
Vinorelbine
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|
| prefixIRI |
NCIT:C1275
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| prefLabel |
Vinorelbine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0078257
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| subClassOf |
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