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Biological and Environmental Research Ontology
| Preferred Name | Triptorelin | |
| Synonyms |
|
|
| Definitions |
A synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels typically observed in surgically castrated men. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1267 |
|
| Accepted_Therapeutic_Use_For |
Palliative treatment prostate carcinoma
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|
| ALT_DEFINITION |
A drug that is used to treat advanced prostate cancer, and is being studied in the treatment of breast cancer. It belongs to the family of hormonal drugs called gonadotropin-releasing hormone analogs.
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| CAS_Registry |
57773-63-4
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| CHEBI_ID |
CHEBI:63633
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|
| Chemical_Formula |
C64H82N18O13
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|
| code |
C1267
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels typically observed in surgically castrated men. (NCI04)
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|
| Display_Name |
Triptorelin
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| FDA_UNII_Code |
9081Y98W2V
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Triptorelin
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|
| Legacy Concept Name |
Triptorelin
|
|
| Maps_To |
Triptorelin
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|
| NCI_Drug_Dictionary_ID |
42944
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|
| PDQ_Closed_Trial_Search_ID |
42944
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|
| PDQ_Open_Trial_Search_ID |
42944
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|
| Preferred_Name |
Triptorelin
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|
| prefixIRI |
NCIT:C1267
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|
| prefLabel |
Triptorelin
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0077275
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| subClassOf |
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