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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Sumatriptan | |
| Synonyms |
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| Definitions |
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1240 |
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| CAS_Registry |
103628-46-2
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| CHEBI_ID |
CHEBI:10650
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| Chemical_Formula |
C14H21N3O2S
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|
| code |
C1240
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| Contributing_Source |
FDA
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| definition |
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.
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| FDA_UNII_Code |
8R78F6L9VO
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Sumatriptan
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|
| Legacy Concept Name |
Sumatriptan
|
|
| Preferred_Name |
Sumatriptan
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|
| prefixIRI |
NCIT:C1240
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| prefLabel |
Sumatriptan
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0075632
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| subClassOf |
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