Preferred Name |
Sirolimus |
|
Synonyms |
|
|
Definitions |
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04) |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C1212 |
|
Accepted_Therapeutic_Use_For |
Kidney transplant rejection, prevention |
|
ALT_DEFINITION |
A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin. |
|
CAS_Registry |
53123-88-9 |
|
CHEBI_ID |
CHEBI:9168 |
|
Chemical_Formula |
C51H79NO13 |
|
code |
C1212 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04) |
|
Display_Name |
Sirolimus |
|
FDA_UNII_Code |
W36ZG6FT64 |
|
Has_Target | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
|
Is_Value_For_GDC_Property | ||
label |
Sirolimus |
|
Legacy Concept Name |
Sirolimus |
|
Maps_To |
Sirolimus |
|
NCI_Drug_Dictionary_ID |
42555 |
|
NSC Number |
226080 |
|
PDQ_Closed_Trial_Search_ID |
42555 |
|
PDQ_Open_Trial_Search_ID |
42555 |
|
Preferred_Name |
Sirolimus |
|
prefixIRI |
NCIT:C1212 |
|
prefLabel |
Sirolimus |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
UMLS_CUI |
C0072980 |
|
subClassOf |
http://purl.obolibrary.org/obo/NCIT_C261 |