loading...| Preferred Name |
Pyrazofurin |
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| Synonyms |
|
|
| Definitions |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1208 |
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| CAS_Registry |
30868-30-5 |
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| Chemical_Formula |
C9H13N3O6 |
|
| code |
C1208 |
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| Contributing_Source |
FDA |
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| definition |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) |
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| FDA_UNII_Code |
4B15044GQZ |
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| in_subset | ||
| label |
Pyrazofurin |
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| Legacy Concept Name |
Pyrazofurin |
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| NCI_Drug_Dictionary_ID |
39575 |
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| NSC Number |
143095 |
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| PDQ_Closed_Trial_Search_ID |
39575 |
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| PDQ_Open_Trial_Search_ID |
39575 |
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| Preferred_Name |
Pyrazofurin |
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| prefixIRI |
NCIT:C1208 |
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| prefLabel |
Pyrazofurin |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide Antibiotic |
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| UMLS_CUI |
C0072661 |
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| subClassOf |