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Biological and Environmental Research Ontology
| Preferred Name | Boceprevir | |
| Synonyms |
|
|
| Definitions |
An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C117292 |
|
| CAS_Registry |
394730-60-0
|
|
| code |
C117292
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.
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|
| Display_Name |
Boceprevir
|
|
| FDA_UNII_Code |
89BT58KELH
|
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Boceprevir
|
|
| NCI_Drug_Dictionary_ID |
763662
|
|
| PDQ_Closed_Trial_Search_ID |
763662
|
|
| PDQ_Open_Trial_Search_ID |
763662
|
|
| Preferred_Name |
Boceprevir
|
|
| prefixIRI |
NCIT:C117292
|
|
| prefLabel |
Boceprevir
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1738934
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |