loading...| Preferred Name |
Miltefosine |
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| Synonyms |
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|
| Definitions |
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1170 |
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| Accepted_Therapeutic_Use_For |
Skin metastasis of breast cancer |
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| CAS_Registry |
58066-85-6 |
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| Chemical_Formula |
C21H46NO4P |
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| code |
C1170 |
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| Contributing_Source |
FDA |
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| definition |
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04) |
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| FDA_UNII_Code |
53EY29W7EC |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Miltefosine |
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| Legacy Concept Name |
Miltefosine |
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| Maps_To |
Miltefosine |
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| NCI_Drug_Dictionary_ID |
41212 |
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| PDQ_Closed_Trial_Search_ID |
41212 |
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| PDQ_Open_Trial_Search_ID |
41212 |
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| Preferred_Name |
Miltefosine |
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| prefixIRI |
NCIT:C1170 |
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| prefLabel |
Miltefosine |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0068006 |
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| subClassOf |