loading...| Preferred Name |
Leflunomide |
|
| Synonyms |
|
|
| Definitions |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1128 |
|
| ALT_DEFINITION |
An anticancer drug that works by inhibiting a cancer cell growth factor. |
|
| CAS_Registry |
75706-12-6 |
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| CHEBI_ID |
CHEBI:6402 |
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| Chemical_Formula |
C12H9F3N2O2 |
|
| code |
C1128 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04) |
|
| Display_Name |
Leflunomide |
|
| FDA_UNII_Code |
G162GK9U4W |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Leflunomide |
|
| Legacy Concept Name |
Leflunomide |
|
| Maps_To |
Leflunomide |
|
| NCI_Drug_Dictionary_ID |
42253 |
|
| NSC Number |
677411 |
|
| PDQ_Closed_Trial_Search_ID |
42253 |
|
| PDQ_Open_Trial_Search_ID |
42253 |
|
| Preferred_Name |
Leflunomide |
|
| prefixIRI |
NCIT:C1128 |
|
| prefLabel |
Leflunomide |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0063041 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C2169 |