loading...| Preferred Name | Genistein | |
| Synonyms |
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|
| Definitions |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1113 |
|
| ALT_DEFINITION |
An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer. An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring. |
|
| CAS_Registry |
446-72-0 |
|
| CHEBI_ID |
CHEBI:28088 |
|
| Chemical_Formula |
C15H10O5 |
|
| code |
C1113 |
|
| Contributing_Source |
CRCH CTRP FDA |
|
| definition |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04) |
|
| Display_Name |
Genistein |
|
| FDA_UNII_Code |
DH2M523P0H |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| INFOODS |
GNSTEIN |
|
| Is_Value_For_GDC_Property | ||
| label |
Genistein |
|
| Legacy Concept Name |
Genistein |
|
| Maps_To |
Genistein |
|
| NCI_Drug_Dictionary_ID |
43214 |
|
| NSC Number |
36586 |
|
| PDQ_Closed_Trial_Search_ID |
43214 |
|
| PDQ_Open_Trial_Search_ID |
43214 |
|
| Preferred_Name |
Genistein |
|
| prefixIRI |
NCIT:C1113 |
|
| prefLabel |
Genistein |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0061202 |
|
| Unit |
mcg |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C599 http://purl.obolibrary.org/obo/NCIT_C1821 |